These sensors enable the dialysis dose to be calculated without additional workload, analytical determinations or cost and quantify the dose received by the patient in each session and in real time [ 1].
The combination may also enable the radiotherapy dose to be reduced without diminishing curative potential, thus limiting radiation morbidity.
In contrast, a PK/PD model of HDL-C and ApoA-I data would enable the selection of dose regimen that achieves their target values, but would not be suitable for assessing the impact of dose regimen on quantities that have not been experimentally measured, such as pre- β1.
Mice were weighed on each treatment day prior to injection to enable the adjustment of dose per individual body weight.
Nevertheless, identification of critical sites of targeted delivery along with increased delivery efficiency would enable the smallest effective dose.
Periodontal disease was defined according to quartiles of either mean full-mouth PD or AL values to obtain a balanced categorization of the periodontal exposure and to enable the assessment of dose responsiveness.
For example, embryos (one or more per well) can be arrayed in multi-well plates and exposed to a series of drug concentrations to enable the maximum tolerated dose of a compound to be determined (Parng et al., 2002; Taylor et al., 2010).
However, this approach will enable the titration of the dose of either agent to optimize target inhibition.
Further studies have been initiated in order to obtain a wider distribution of peak levels which will enable the establishment of dose-response relationships.
The question of whether time or concentration drives the efficacy of a given drug has been used to enable the selection of dosing regimens that optimize clinical efficacy while suppressing the emergence of resistant organisms, as well as to determine clinically relevant susceptibility breakpoints (12).
