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GNAQ encodes the alpha subunit of a q class of heterotrimeric GTP binding proteins (Gq) that enable signaling from the cell surface to the protein kinase C (PKC) protein and finally the MAPK pathway.
In addition, a few recent papers describe reagents that enable signaling pathways to be driven in response to light, including the creation of the second messenger cyclic AMP (cAMP) in response to light [59], or optical control of the beta-adrenergic signaling pathway using a beta-adrenergic receptor/rhodopsin hybrid protein [60].
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The recently emerged optogenetic tools open exciting opportunities by enabling signaling regulation with superior temporal and spatial resolution, easy delivery, rapid reversibility, fewer off-target side effects, and the ability to dissect complex signaling networks.
It is this robustness feature of EGFR signaling cascades which enables signaling in tumour cells to be so resistant to anti-cancer therapeutics.
The exosome probably serves as a kind of 'shelter' that enables signaling proteins to avoid degradation in the ECM and thus serves as a cargo-carrier for transmitting a variety of 'stress signals', including but not limited to caspase-3.
A properly formed yolk sac together with early placental structures supplies the embryo with nutrients and enables signalling between the embryo and the mother.
This protein protein interaction enables signalling through the IKK NF-κB pathways.
Binding of secreted FGFs with heparan sulphate proteoglycans enables signalling through receptor tyrosine kinases to activate MAPK and PI3K/AKT pathways which contribute to tumour growth and angiogenesis [ 67].
His research concentrates on the ways in which neurons take on specialised functions to enable signalling in the brain.
IN_EN is enable signal for data input.
(32 where 'Enb' represents the enable signal of PRG.
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