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However, since very low titers of neutralizing antibodies can inhibit AAV transduction, it is unclear if a reduction in anti-AAV titer would be sufficient to enable productive transgene expression, particularly in the presence of long-lived plasma cells.
Lighter planning rules would enable productive industries to grow: Oxford, for instance, has one of the world's leading medical schools, but its tight "green belt" of land that is off-limits to developers makes it hard to find space for life-sciences firms to flourish.
To evaluate the ability of SVP[Rapa] to enable productive re-dosing of AAV vectors, male C57BL/6 mice were treated first with an AAV8 vector expressing luciferase (AAV8-luc) at day 0, followed by a second administration of an AAV8 vector encoding for human coagulation factor IX (AAV8-hF.IX) on day 21.
To enable productive linguistic and language-technology research in the future, they are adding respeaking, in which native speakers listen and repeat each phrase slowly and carefully, as well as oral translation, in which bilingual speakers of the language translate the recordings phrase by phrase into a widely used language such as English.
The Zhang Research Group in the School of Electrical and Computer Engineering at Cornell University investigates new applications, programming models and computer-aided design (CAD) algorithms and tools to enable productive design and implementation of highly efficient application- and domain-specific computer systems.
Mobile enabled fee-for-service (utility) business models, the establishment of a service network, awareness raising campaigns on the benefits of clean cooking, female-focussed training programmes and bundling eCook systems with locally appropriate appliances to enable productive activities are seen as key to reaching scale.
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A current paradigm posits that the irreversible transition from an inactive zymogen to the active protease form enables productive interaction with substrate and catalysis.
"This software feature could also be seen as an embodiment of Wikipedia's neutrality principle, in that it brings together editors from different political systems and enables productive discussion and collaboration between them," Mr. Roth said.
But complexity also factors in the infrastructure and institutions that facilitate the aggregation of knowledge, such as reliable transportation and communication systems, and a culture of trust that enables productive collaboration.
However, in many areas, soil conservation practices and reforestation with exotic conifers have enabled productive uses to continue.
Our department can help Duke community members navigate increasingly complex risk and regulatory environments while still enabling productive work.
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CEO of Professional Science Editing for Scientists @ prosciediting.com