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Protein expression profiling in the subcellular compartment where a given ubiquitin ligase resides would enable more sensitive detection of its ubiquitination substrates.
Furthermore, any reduction in the inter-individual variability of growth and development will enable more sensitive assessment of the possible effects of a test compound on the development of tadpoles.
Culture systems are sensitive, but often take up to four weeks to obtain conclusive results even with enhanced culture systems and these approaches to enable more sensitive and rapid TB diagnosis are not yet available in most developing country settings [ 9].
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Co-immobilizing miniature sensors alongside cells enables more sensitive detection of secreted factors and may allow for such detection to happen within the context of local microenvironment.
In the case of PET, faster scintillation crystals with high stopping power such as LYSO crystals have enabled more sensitive devices to be built, making it possible to reduce the number of undesired coincidence events and to use time of flight (TOF) techniques.
Recently, high-density Affymetrix array data for rice has become publicly available, thereby enabling more sensitive co-expression profiling analysis for rice [20].
To increase the accuracy of detecting a single viral particle, a fluorescence-activated cell sorter (FACS) AriaII with a forward scatter photo multiplier tube (PMT) was used, which enabled more sensitive detection and lower size thresholds (Figure 2).
IPD adds more power by controlling for between study confounders and by enabling more sensitive modelling of the age-effect relationship [ 31].
However, we find that tyramide signal amplification enables more sensitive detection of activated caspase-3 and allows for detection in degenerating axons.
Using time-gated acquisition the background signal can be efficiently suppressed, enabling more sensitive detection of proteins using lanthanide chelate tags than is possible with chromophore-based or conventional fluorophore-based labels.
These data suggest that the modified protocol of the large volume kit has comparable performance with the total nucleic acid kit for the extraction of samples containing high SARS-CoV concentration, but enabled more sensitive detection when samples containing low levels of SARS-CoV were extracted.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com