The main limitation of the evaluation was the lack of time and funding to enable more extensive community feedback and verification of the findings.
Indeed, the comprehensive phenotyping of mutants, which is a common practice in mice [ 4] for example, has begun in quail [ 5, 6], but more contributions are needed to enable more extensive comparisons between mammals and birds.
The existence of an outgroup of nitrogenase homologs (termed Group IV) has been noted previously [ 27], but the current availability of genome sequences has enabled more extensive analysis.
toxoMine complements the major community database ToxoDB by providing a data warehouse that enables more extensive integrative studies for T. gondii.
toxoMine complements the major community database ToxoDB by providing a data warehouse that enables more extensive integrative studies for T. gondii; therefore, we believe it will become an indispensable resource to the greater infectious disease research community.
More recently, the use of genome-based approaches has enabled more extensive investigations of sources of systematic bias, or inconsistency in phylogenetic analyses [ 102, 106- 108] and identified new effects difficult to detect in smaller data sets, such as site-specific changes in evolutionary rates among lineages, or heterotachy [ 109- 111].
While this method does not account for binucleation, as described by Walsh et al. (21), it has the advantage of enabling more extensive coexpression analyses, while still demonstrating relative proportions of cell types and changes in them, if not absolute numbers in individual hearts.
Furthermore, introduction of a simple post-fixation bleaching step as an alternative to extensive clearing procedures in the original technique has simplified the processing steps to enable more efficient staining of tissue.
For communities with extensive heterogeneity in contact patterns, however, network models more explicitly capture patterns of disease transmission and thus enable more accurate and detailed predictions of the effect of control measures on the magnitude and distributions of outbreaks.
We are currently developing extensions to increase the computational speed of LOCate, which will enable a more extensive range of simulations to compare LOCate's performance to LOT on a variety of ordinal and nominal traits with varying amounts of missing data and inbreeding.
