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Each individual mouse V t) in the control group was fitted with the exponential growth function to enable extrapolation of the growth beyond the time when the tumor volume exceeded the maximum.
These methods do not enable extrapolation of the thickness trends to areas where there is no deposit exposure, and therefore estimates constitute a minimum erupted volume, thus allowing direct comparison with volumes determined by integration of the spline surface.
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Another strength is the large sample of hospitals and stratification by hospital type and location, which enabled extrapolation of the results to a national level.
Normalized sample weights provided in the DHS data were used for this analysis, employing Stata version 10 (StataCorp, College Station, TX, USA) to adjust for nonresponse and enable extrapolation of findings to the general population.
To accommodate future discoveries within the framework of the biological model, one may include knowledge about biological structures and mechanisms that enable extrapolation of unobserved scenarios.
To enable extrapolation of observations from included animal studies toward post-AMI clinical trials, ex vivo studies on isolated hearts and proof-of-principle studies on inhibitor administration before experimental AMI induction were excluded.
Moreover, population models may enable extrapolation of long-term efficacy and safety based on short-term pharmacokinetic and treatment response data.
This enables extrapolation of explored variables to the true population at risk.
All these data were used to model the exponential decay of the FDR with respect to increasing peak height and peak width, therefore enabling extrapolation of FDR values for higher and broader peaks.
Initially, micro-indentation of individual skin strata revealed hyperelastic moduli were dramatically rate-dependent, enabling extrapolation of stiffness properties at high velocity regimes (>1 ms−1).
The pharmacokinetic profile and mean serum exposure of patients and HMVs receiving trastuzumab IV 6 mg kg−1 were comparable (mean Cmax: 185 μg ml−1 vs 150 μg ml−1, respectively; Figure 2B, Supplementary Table S1B), enabling extrapolation of results in HMVs to patients.
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