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Technological innovations enable dose reduction, thus lowering the chance of adverse effects.
Additionally, with regard to planning procedures for radiotherapy, the use of FDG-PET for target volume definition may enable dose escalation, a lower exposure of organs at risk, as well as reduced interobserver variability [6, 7].
Hyperfractionation is simply the tool to enable dose escalation without an increase of severe late toxicity.
Identification of (causal path) biomarkers could enable dose optimization and monitoring of response based on the changes in levels.
Examining consistency of effect across multiple clinical endpoints in a proof-of-concept study may identify efficacious therapies and enable dose selection for confirmatory trials.
IMRT and IGRT enable dose escalation to the target volume and permit delivery of a simultaneous integrated boost to a GTV; randomized trials are needed to determine if there is a clinical outcome benefit with acceptable toxicity.
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Our automated control platform is an innovative tool to enable dose-response studies of small molecules and investigation of gene dosage effects in disease.
The modified Tactipen® used in EDITION 3 allowed smaller increment steps (1.5 U) compared with the modified SoloSTAR® pen (3 U), to enable dosing for an insulin-naïve population with a wide range of insulin requirements.
The linac is a Siemens Oncor without a flattening filter, and enables dose rates to reach 1000 monitor units (MUs) per minute.
Prostate radiotherapy has also evolved with these technological advancements, enabling dose escalation.
118, 119 With the increasing use of IMRT, enabling dose escalation and the associated steep dose gradients, it is critical to accurately localize the target for precise treatment delivery.
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