When the base of the tumor is clearly demonstrated endoscopically, ESD enables curative resection by removing the tumor base.
Colonoscopy at this stage, however, is not performed for the detection of locoregional recurrence of primary cancer, enabling curative treatment, but it is performed for the detection of metachronous colorectal cancer [17].
In our patient, the tumor was detected by conventional CT and MRI scans as a isolated, well-contained mass without metastasis to the liver or lymph nodes, which enabled curative resection.
Remarkably, two patients from our trial were sufficiently downsized to enable potentially curative resection of ⩾3 hepatic segments.
Two patients (4.0%) experienced sufficient reduction in the volume of their liver metastases to enable potentially curative resection of ⩾3 segments.
Arguments usually address the risk of local recurrence, enabling a curative resection and facilitating sphincter-sparing surgery, rather than the integration of systemic chemotherapy and the high risk of metastatic disease.
As in selected patients therapy with modern chemotherapy protocols may cause marked tumour regression that may enable further therapeutic action with curative intent, colonic resection with adequate lymphadenectomy is recommended, though this is not mandatory requirement and the decision to perform lymphadenectomy remains at the discretion of the executing surgeon.
Currently, no curative strategies enable clinicians to treat such established damage, and AKI is clearly associated with an increased independent risk of in-hospital mortality and CRI within a few years following AKI [16 21].
The precise identification of the site of biochemical recurrence of prostate cancer is important as it enables initiation of curative treatments such as radiotherapy and surgery.
There remain a number of challenges to enable a shift from a curative to a preventative focus for childhood obesity in primary care.
