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The solubility in polar media and the presence of the carboxyl group enable coupling to biomolecules such as proteins, antibodies or lipids.
Such sequences are playing an increasingly prominent role in post-transcriptional control devices: by serving as allosteric sites built into mRNA transcripts, they enable coupling between exogenous ligand concentrations and translation rates.
These advantages enable coupling of other, physical forces-based cell sorting and manipulation methods, i.e. magnetic, electric, acoustic or optical, into a microfluidic system as well as integration with other microfluidics devices for simultaneous analysis of a sample.
Specifically, removal of 62 72 residues from the cytoplasmic C-terminus of the receptor was required to enable coupling, suggesting that ligand-dependent conformational changes do not efficiently propagate to the distal C-terminus.
The Fmoc group was then removed to enable coupling with Boc-methotrexate or gemcitabine-ester.
This position shall enable coupling to each modified antibody, independent of the hapten that is applied for payload positioning.
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20 For the first time Ir OEP CarbIm2 enables coupling to silica gel via the axial ligand (τ0= 26 μs) instead of modifying the porphyrin macrocycle.
In a previous study, we synthesized a derivative of SM-designated UC1V150, in which the aldehyde functional group on the benzyl moiety enabled coupling the agonist to different auxiliary chemical entities through a bifunctional linker molecule containing a hydrazine and N-hydroxysuccinimide activated ester function (9).
This enables coupled, three-dimensional vibration problems to be solved very efficiently using a two-dimensional approach.
The implementation of the TH code with AGENT enables coupled thermal-hydraulic and neutronics analysis in providing the average reactor fuel temperatures.
Third, we modify Hsp104 to interact with the chambered protease ClpP, which enables coupled remodeling and degradation to irreversibly clear SEVI and PAP85-120 fibrils.
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