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In contrast to previous conclusions, we show that only one of the catalytic domains must be proteolyzed to enable activation.
To determine whether the deactivation of excitatory neurons in the contralateral PL is required for pain-induced behavioural impairments, we used optogenetics techniques that enable activation or inhibition of cell-type-specific neurons.
Thus, the engineered expression system of ATFs may enable activation of VEGF-A expression specifically in ischemic tissues without affecting normal, healthy tissues in vivo.
The approach of chimeric flagellin can therefore generate effective immunogens that enable activation of innate and adaptive immune response and can be used to construct efficient vaccines against H. pylori or other flagellated bacteria that evade TLR5 recognition.
Catalysts incorporating acid and base cooperative interactions can more efficiently catalyze the aldol and nitroaldol reactions than single component catalysts since cooperative interactions enable activation of both reaction partners.
The need of a sufficient amount of vaccinated DC to enable activation of effector cells has already been suggested not only in murine models [75], but also in clinical trials [76].
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It has also been shown in mice that suppression of mTOR activity at birth enables activation of autophagy49.
This enables activation of FT, is a potent activator of flowering in A. thaliana (Searle et al., 2006).
Our results further support a model for OMP assembly in which communication between BamA and BamD enables activation of both components, although the need for interaction can be bypassed through activating mutations in BamA and BamD.
Molecular steps enabling activation of SOCE via CRAC channel clusters remain incompletely defined.
Delivery of multiple sgRNAs further enables activation or repression of multiple genes.
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