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Short interfering RNA (siRNA) based screening may facilitate the identification of genes and pathways essential for cancer cell survival and could enable a more targeted therapeutic approach for the treatment of GBM.
Using this 2-step diagnostic approach would enable a more targeted and cost-effective diagnostic of respiratory disease.
Our review emphasizes on the strengths, pitfalls, and limitations of microscopic features as well as immunohistochemical and polymerase chain reaction- (PCR-) based tests used by laboratories to screen for DNA mismatch repair (MMR) and PTEN gene mutations in patients to enable a more targeted and cost effective approach in the use of confirmatory gene mutational analysis tests.
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Therefore, identification of more sensitive biomarkers of pre-radiographic joint tissue turnover have the capacity to reflect disease relevant biological activity and provide useful diagnostic and therapeutic information, enabling a more rational, targeted and individualized approach to disease management.
A higher postural balance confidence during swing phase of the gait cycle has possibly enabled a more accurate targeting.
This in turn will enable a more reliable assessment of PPI target druggability and tractability by fragment screening and better inform the prioritization of PPI targets for drug discovery programs.
To enable a more specific evaluation of angiogenesis, target-specific imaging methods have been developed for PET and SPECT imaging, MRI, ultrasound as well as optical imaging [ 14].
Similar approaches could be extended to L. cuprina and other related blowfly species, to enable a more comprehensive assessment of novel insecticide targets.
In the critical care setting, continuous infusion (CI) of vancomycin may enable a more rapid and consistent attainment of target drug concentrations than standard intermittent administration [ 11].
A more systematic investigation of the consensus CPE sequence and its maximum distance to the poly(A) signal would enable a more reliable bioinformatic prediction of the targets of CPE-mediated cytoplasmic polyadenylation.
Bait stations have been used successfully for oral rabies vaccination in raccoons (10 ) and may enable more targeted bait distribution in areas of high raccoon density.
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