As these pathways are activated in ob/ob islets and not in POKO islets, and that this is occurring very early before ob/ob islets fail, we speculate that this immune and inflammatory response may in fact be a physiological response, initiating or enabling a mechanism of remodelling or adaptation in order for the β-cell mass to expand.
In contrast, M&S can optimise the use and interpretation of those data, enabling a mechanism-based, systematic extrapolation of the data across species (e.g. scaling exposure findings for differences in metabolic clearance).
Structural studies reveal that the fold of these two enzymes is remarkably similar, with equivalent positioning of the [Fe-S] clusters enabling a similar mechanism of ATP-driven electron transfer from the reductase protein, to the catalytic component.
A custom designed stimulation probe could enable a safe mechanism for early detection of the facial nerve during MICI.
The ability to immortalize feline ECs, and the fact that these cells maintain the EC phenotype will enable a greater understanding of fundamental mechanisms of EC biology and endothelial-related diseases.
Therefore, understanding the molecular mechanisms that enable a subset of normal HMECs to withstand anoikis and generate MS is likely to provide important insights into normal mammary gland biology, as well as breast cancer progression.
For this reason, the understanding of gene expression profiles, which provide signatures of all the active genes and their interconnections in a cell, contain valuable information about the functioning of key pathways, as expressed by the hallmarks of cancer and, hence, enable a practical investigation of functional mechanisms thereof [ 28- 36].
Further characterisation of the molecular events within mitochondria that lack PINK1 will enable a better understanding of the pathophysiologic mechanisms that cause the phenotype of PINK1 loss-of-function.
By the integrative exploitation of genomic, phenomic and environmental information, translational bioinformatics will enable a deeper understanding of disease mechanisms (2).
It may be a homeostatic mechanism [10], [13] to enable a balance of LTP and LTD in the amygdala in vitro[14].
