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Our experiments were performed in myofibers containing at least a few empty nuclei.
Note that there is a slight accumulation of GFP-fusion protein at the transcription loci of the reporter mRNA, resulting in a small spot visible inside the empty nuclei [18].
Hematoxylin and eosin stained slides were examined by study pathologists to identify areas with classic characteristics of PTC, including papillary architecture, typical PTC nuclei (enlarged, overlapping, irregular, ground-glass empty nuclei with nuclear grooves), psammoma bodies, and stromal reaction 27.
Parameter estimates from the regression model suggest that the odds ratio for empty nuclei was 1.71 (95% confidence interval (CI) 1.59 to 1.83) for the posterior approach group versus the non-posterior group; i.e. the data indicates that there were significantly more empty cells in the posterior approach group than the non-posterior group.
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Although the existence of an empty nucleus is hypothesized [19] (i.e., the word is in actually pronounced with an additional syllable, like 'adivogar'), this work chose to follow the orthography and other studies [27] and kept the voiceless consonant in the same syllable (e.g., 'advogar' <ad-vo-gar >).
Kwok et al. (Kwok et al., 2016) observed visually prominent cell death (denoted by empty lacuna and pyknotic nuclei) only in menisci from OA murine knees, but not in menisci from normal aging mice.
Identification of ON lesion was performed using established criteria, i.e. diffuse presence of empty lacunae or pyknotic nuclei of osteocytes in the trabeculae accompanied by surrounding necrotic bone marrow [20] [21].
Osteonecrosis was judged to be present when there was necrosis of medullary hematopoietic cells or fat cells or there were empty lacunae or condensed nuclei in osteocytes.
Positive diagnosis of osteonecrosis was made on the basis of the diffuse presence of empty lacunae or pyknotic nuclei of osteocytes in the bone trabeculae, accompanied by surrounding bone marrow cell necrosis or myelofibrosis as described in [ 21].
The histopathology of osteonecrosis generated in this model was characterized by empty lacunae or pyknotic nuclei of osteocytes accompanied by surrounding bone marrow cell necrosis, which was similar to osteonecrosis in steroid- treated patients.
A positive diagnosis of osteonecrosis was determined based on the diffuse presence of empty lacunae or pyknotic nuclei of osteocytes within the bone trabeculae, accompanied by surrounding bone marrow cell necrosis or fat cell necrosis (Yamamoto et al. 1997).
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