For a given value of the sample size g, we first compute Equation (4) for each of the 2 J − 1 non-empty combinations possible for a set of J populations.
One possible approach to calculating directly standardised rates when there are empty casemix combinations is to differentiate between casemix standardisation and risk adjustment.
Thus standardisation for casemix indirectly via SMRs cannot yield fair comparisons, but the correct way (direct standardisation) also may not work because of different patterns of empty casemix combinations and is not possible with continuous covariates.
We have suggested that one approach to get around the problem of empty casemix combinations in conventional direct casemix standardisation might be to re-calculate the weights actually used in each centre so that they always sum to one.
It follows from this that a solution to the difficulty of calculating directly standardised rates in the presence of empty casemix combinations is to convert the complex multidimensional casemix to a simple one-dimensional risk distribution and then directly standardise across the risk distribution.
For example, if there are 2| C |−1 rows and the signature of each row is the same as its index, i.e., the first row has signature 000...001, the second row has signature 000...010, the third row has signature 000...011, and so on, then each of the 2| C |−1 non-empty column combinations participates in a different maximal MTB.
Statistical background for no significant interaction has been calculated from enzymatic activity of empty AD-clone combinations.
MBDDrh of empty region-hemisphere combinations was set to half the number of artifact-free epochs of a subject for easier algorithmic calculation [ 43].
(c) PKM2 enzymatic activity was evaluated in lysates of HEK293T cells transfected with JNK1 constitutive active (JNK1CA; 15 μg) or control empty vector in combination with HA-PKM2 WT) HA-PKM2 WT(T365A) (15 μg).
Cells were cotransfected using lipofectamine with either 200 ng NRBP1 shRNA vectors or empty vector in combination with either 150 ng M50 Super 8x TOPFlash or M51 Super 8 × FOPFlash and 50 ng Renilla (pRL-SV40) plasmid.
After 17 hr, cells were released using 24 μM deoxycytidine and simultaneously transfected with untagged, wild-type CENP-A and/or HJURP expression vectors (or an empty vector) in combination with an EYFP-CENP-C expression vector (Shah et al., 2004) (2 2 1 proportion).
