Despite these encouraging early results, the specific mechanisms behind the observed functional improvements remain to be fully explored and future studies employing hypothesis-driven material design and selection may increase the potential of this approach to alleviate the morbidity and mortality of heart failure.
Given the high dynamic range of proteins in biological systems, this problem is inherent to global screening proteomic experiments, and is only solvable employing hypothesis-driven proteomics strategies (targeted proteomics).
Peer interactions in the shared learning condition were structured so that learners were encouraged to employ hypothesis testing strategies.
The first used descriptive statistics and the second employed hypothesis evaluation statistics.
Since the majority of the 213 miRNAs was identified in all three tests, the data demonstrate a high concordance of the employed hypothesis tests.
We first employed hypothesis-testing to determine, by coalescent simulation, whether a range of growth models could be rejected in favor of constant size using the method pioneered by Pluzhnikov et al. [20].
Practice style differences, diagnostic and therapeutic uncertainties in clinical medicine and supplier-induced demand are the most widely employed hypotheses to explain these variations [ 27].
To date, we have successfully employed hypothesis-driven approaches to identify neuro-molecular mechanisms of seasonal variation in peripheral auditory function, namely in the hair cell epithelium and eighth nerve afferents of the saccule, the main auditory division of the inner ear in many teleost fish including midshipman [ 8, 15].
An attempt was made to explain the observed deviation employing the hypothesis of immobilized entanglements.
The study employs multiple hypothesis testing, where each hypothesis was analyzed separately and the existence of patterns in results and the consistency of the results were considered in the analysis [ 25, 26].
Therefore, employing a hypothesis-free approach we investigated genome-wide influences on optimum racing distance by conducting a genome-wide SNP-association study in a cohort of elite Thoroughbred racehorses.
