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Subsequently, ADMET, DFT and chemical similarity search were employed to narrow down on seven compounds as potential drug candidates.
Next, site-directed mutagenesis was employed to narrow down the TtrD binding epitope still further.
Further, a Disease Burden Index (DBI) is employed to narrow the focus of the CCP to DH members with the greatest complexity and highest disease burden.
HMM and BLAST-based search methods were used to identify AD domain-encoding genes, and domain architecture predictions were employed to narrow this list to likely ADAR candidates (Additional file 1).
While we currently cannot make any strong claims about genotype phenotype correlations regarding cases of familial EL, this work is a starting point and a proof-of-principle that such an approach can be employed to narrow down lists of candidate genes contributing to human EL, analogous to that used to pinpoint disease-causing mutations in rare Mendelian disorders.
Within each fold, first a test of differential abundance between the CRC group and the controls was employed to narrow down the candidate list to a subset of significant proteins changing in abundance in CRC (P-value ≤ 0.05, FC cutoff ± 1.1) (Appendix Table S2A).
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In this section, making use of audio podcast knowledge, a fuzzy neural classifier is employed to quickly narrow the search area of the huge collection data.
A binary logistic regression with backward selection option was employed to further narrow down significant symptoms.
An increase in class four national insurance rates for the self-employed, to narrow the gap with salaried employees, who tend to be taxed more heavily, was one of the most conspicuous measures in a cautious budget that also saw the chancellor upgrade his economic forecasts.
In [9], a prediction-error filter is employed to detect narrow-band interferences, and then, erasure insertion is performed over the detected superposed bands.
Mining algorithms often employ constraints to narrow down the search space in order to increase efficiency.
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