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Preclinical mouse models have employed targeting of a single tumour antigen with some success.
Because our study lacked data on child anthropometrics, we can neither confirm that the government has achieved its vision of how targeting should work, nor that child anthropometrics are improving in response to the employed targeting scheme.
Commonly employed targeting groups include folate-capped lipids that have a preference for rapidly dividing cells overexpressing the folate transporter, and glycolipids that are selective for diagnostic cell-surface lectins on cancer cells.
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Herein, we employed targeted metabolomics and comprehensive bioenergetic analyses to evaluate oxidative metabolism and respiratory kinetics in mouse models of total body (TKO) and skeletal muscle-specific (TXNIP SKM-/-)) TXNIP SKM-/-ency.
Here, we employed targeted proteomic profiling of 80 glycoprotein biomarker candidates across plasma samples of a well-annotated patient cohort with comprehensive CRC characteristics.
We employed targeted re-sequencing of functional regions of the ESR1 gene in patients with schizophrenia to identify rare genetic alterations that may be specific to the disorder.
In an effort to better define the molecular and cellular determinants of NF1 disease pathogenesis in vivo, we employed targeted mutagenesis strategies to generate zebrafish harboring stable germline mutations in nf1a and nf1b, orthologues of NF1.
To determine whether the c.-28A>G and c.-7C>T variants were in cis with another pathogenic sequence alteration within MLH1, we employed targeted, high-throughput sequencing of constitutional DNA from Proband 32.
The VelociGene® method for the creation of targeted mutations in ES cells employs targeting vectors, called BACVecs, that are based on bacterial artificial chromosomes.
The specific integration sequences were obtained using a modified tpTAIL-PCR, employing targeting primers annealing to conserved regions of LINE-1, which demonstrated that kDNA sequences integrate consistently into retrotransposable elements within the human host genome.
Protein fusion biobetters employing targeting approaches are touched upon as well.
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