However, the measurement tools for assessing the environment and the employed study designs have limited our ability to gain important ground.
Overall, any interpretation of the reported results is severely limited by a lack of detail in the employed study designs that were often not suited to answer the self-defined research question [ 19, 21, 24, 28, 30].
Using a data extraction form, we extracted relevant study characteristics (e.g. document classification, study design, method employed, study population, main outcomes).
No studies within the best evidence synthesis employed a study design assessing IMJTs discriminant validity, to investigate the difference between known groups.
The initial Swedish studies (Ekbom et al, 1992, 1997) employed a study design that was similar to that of the present study.
Many cross-sectional studies of neighbourhood effects on health do not employ strong study design elements.
Three studies that employed unique study designs are described below that resulted in the identification of additional novel disease loci for disease progression.
Both of the studies investigating post-infective fatigue investigated different viral infections (enterovirus vs. EBV) and the two studies employed different study designs, cross-sectional [24] and repeated measures [41].
We employ two study designs for a more detailed examination of creativity in the opportunity identification process.
In addition, undertaking evaluation studies by employing rigorous study designs are warranted.
Gathering this information from literature is very laborious because it is scattered across many publications and different studies employ different study designs.
