Sentence examples for employed for discovery from inspiring English sources

Within the vast range of heterocycles, benzimidazole and its derivatives are found to be trendy structures employed for discovery of drugs in the field of pharmaceutical and medicinal chemistry.

A label-free mass spectrometry-based strategy was employed for discovery phase analysis of fractionated patient serum samples associated with no or high bone disease.

Many of the filtration procedures used in di-allelic SNP discovery in the octoploid GDP were also employed for SNP discovery in F1D as described in Additional file 9. Importantly, in the discovery of F1D SNPs, the Upsafe-DownSafe filter employed all of the octoploid GDP VCFs as well as the F1D VCF to maximize the likelihood that F1D-based probe sites would also be conserved in octoploid germplasm.

The technology is now frequently employed for biomarker discovery and for elucidating the mechanisms underlying endocrine-related diseases.

The results indicate that the idea of aligned pharmacophore models can be successfully employed for the discovery of dual-target ligands.

The attendant computational approaches employed for the discovery and initial characterization of DNA variants are discussed with an emphasis on the most commonly used Sanger-based sequencing methodologies.

Structure-based approaches such as docking and molecular dynamics calculations have also been employed for the discovery of new multi-target ligands such as BuChE inhibitors/hCB2R and MAO-A/MAO-B/AChE/BuChE ligands to treat neurodegenerative diseases [25].

Here, we describe the types of tumor antigens which are considered as targets in the design of T cell based therapeutic approaches, the rationale for targeting MHC I antigens and the analytical tools commonly employed for the discovery of MHC I presented peptides.

Compound 4a (IC50 = 6.5 ± 0.1) was found to be most potent compared with the reference compound Galantamine (IC50 = 6.6 ± 0.00038) and the other compounds (4b,4c,4d) were also possess that activity and hence can be employed for the discovery of lead compounds against Alzheimer's disease.

Recently larvae have also been employed for drug discovery [17], [18].

Although metagenomics has been previously employed for pathogen discovery, its cost and complexity have prevented its use as a practical front-line diagnostic for unknown infectious diseases.