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Future models should permit oscillatory solutions that satisfy known empirical targets, especially since the qualitative and quantitative impacts of the vaccine could be very different for oscillatory solutions versus steady state solutions.
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The main outcome investigated in this study was the rate of empirical target non-attainment using a theoretical target MIC of 2 mg/L.
Mean CrCL values ≥ 200 ml min over the three first days of antimicrobial therapy were statistically associated with empirical target non-attainment (OR 9.2 [2.2–38.5], p = 0.001).
The main PK PD outcome investigated in this study was the rate of empirical target non-attainment using a theoretical target MIC of 16 mg L−1 for piperacillin and 2 mg L−1 for tazobactam.
Using a MIC of 16 mg L−1 for piperacillin, the rate of empirical target non-attainment in the overall population was 17%, with a strong association with CrCL (Fig. 1).
But now for the first time we have an empirical target that promises to restore many of the world's degraded reefs and ensure they are best able to handle new threats to the precious oceans that cover nearly three-quarters of our planet.
If the MIC of the pathogen is not known, an empirical target Css of 20 25 mg/L can be used.
First the empirical target distribution was estimated by averaging the (ordered) signals over all arrays, followed by normalization of each array toward this target distribution.
Fibrinogen concentrate administration was guided by FIBTEM (clot strength in the presence of platelet inhibition) using the empirical target MCF of 22 mm with an arbitrary limit for the maximal dose set at 6 g fibrinogen concentrate.
Interestingly, Chatelut et al, 2000 has recently published an investigation where an empirical target AUC of 20 mg min ml−1 and individual clearance based on the formerly developed equation was used.
Up to now, only few randomized-controlled trials compared antibiotic treatment with placebo or different therapeutic strategies, i.e. empirical, targeted or delayed antibiotic treatment in uncomplicated UTI [ 12- 14].
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