Sentence examples for empirical replacement from inspiring English sources

In each case, the proposed methodology leads to the suitable recipe from comparison of traditional and empirical replacement procedures generally used in the pharmaceutical industry.

Because objective measurement of coagulopathy is often unattainable in the clinical setting, current guidelines recommend empirical replacement therapy for the coagulopathic patient with diffuse microvascular bleeding [ 8, 12].

Our post-hoc analyses identified patients who were believed by their treating physicians to have clinically significant coagulopathic bleeding, as reflected by the empirical replacement therapy that was administered.

In particular more reliable empirical replacement matrices [ 31], and models that account for heterogeneities across sites [ 32] and among lineages [ 33] may significantly improve the fit of data to the model and therefore provide more reliable phylogenetic estimates.

Here, we try to estimate selective constraint for each type of amino acid replacement by maximizing the likelihood of individual empirical substitution matrices.

However, in all empirical substitution matrices unnegligible amounts of rates are assigned to amino acid replacements that require multiple nucleotide changes.

Briefly, MEC expands an empirical amino acid replacement matrix –in our case the WAG matrix [ 80], the best scoring one as determined by ProtTest [ 81] among those available in the selecton algorithm- into a codon replacement matrix.

A mechanistic codon substitution model, in which one can change a genetic code, and adjust mutational tendencies at the codon level and selectional preferences on amino acid replacements, is potentially more superior than empirical codon substitution matrices.

Literary accounts are no replacement for empirical studies or professional services; but they can hold up individual experience in such a way that it catches the light for others watching.

ClustalW [ 83] combines an empirical model of residue replacement with gap penalties for adding new gaps and extending existing ones.

On the other hand, the procedure I considers separate resampling with replacement from the empirical distribution of survival times and the empirical distribution of censoring times.