Your English writing platform
Discover LudwigExact(6)
The main causes of non-compliance with empirical protocols have not been clearly described.
We detail empirical protocols for estimating power and type I error rates for parametric, nonparametric and randomization methods, and demonstrate their application for an analysis of variance and a regression/correlation analysis design.
Furthermore, M&S can overcome many of the pitfalls associated with the use of empirical protocols and isolated, sequential developability criteria.
Nevertheless, accurate evaluation of the benefit risk balance of treatments aimed at prophylaxis and/or modification of disease progression will remain a burden by using empirical protocols, even when longitudinal follow-up is well designed and outcomes strictly defined.
The use of empirical protocols to assess cardiovascular risk in patients clearly entails large complexity and adds long safety trials that may last for several years, without necessarily providing further insight into the processes that determine disease progression.
In addition to the role of mechanistic models, which are surfacing from research in systems biology and systems pharmacology, and their contribution to the rationale for patient selection and paediatric dosing regimen, practical and ethical limitations imposed by empirical protocols are highlighted.
Similar(53)
The glass transition is found in the region from −50 to −45°C depending upon the empirical protocol.
We designed training software that target specific communicative disorders attributed to autism and defined an empirical protocol to test this software.
Using an empirical protocol that we have previously developed to generate embryo-derived RoSH lines with endothelial potential, we first generated E-RoSH lines from mouse ESC-derived embryoid bodies (EBs).
Since ESC-derived embryoid bodies (EBs) are developmentally analogous to early post-implantation embryos[20], we rationalized that exposing EBs to the empirical protocol for deriving RoSH cell lines could also generate RoSH-like cells.
Nevertheless, this empirical protocol generated the critical purified cells for a genome-wide panning for candidate genes encoding surface markers that were differentially expressed in RoSH-like cells versus ESCs, and culminated in the identification of CD9hi SSEA-1− cell population as RoSH-like cell population in differentiating EBs.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com