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These patients had no evidence of IFDs and would not have received treatment via an empirical fever-driven strategy.
We discuss the empirical treatment of fever in relation to these findings.
This subgroup of febrile neutropenic patients with LI should be treated with a broad-spectrum β-lactam with antipseudomonal activity, as used for empirical treatment of fever of unknown origin (A-II).
This resistance may complicate empirical treatment of enteric fever.
He was treated with empirical meropenem and his fever resolved after 3 days.
This could show how many patients would receive a misdiagnosis on the basis of a fever driven empirical approach without regarding results from sensitive and specific biomarker testing.
There were no significant differences between the two groups in frequency of defervescence or duration of fever during empirical antibiotic therapy (Table 2).
The empirical antimicrobial regimen of fever and neutropenia does not cover C. difficile and fosters the production of C. difficile toxins [ 32].
In our hospital, antifungal prophylaxis and antifungal therapy are performed in accordance with the recommendations of the committee for "Guidelines for the Empirical Therapy of Neutropenic Fever Patients based on Literature in Korea" [ 23].
The initial empirical treatment of neutropenic fever in hematological malignancy patients is to use anti-pseudomonal cephalosporin (cefepime or ceftazidime) and/or an aminoglycoside (isepamicin), excluding the initial use of glycopeptides.
For this reason, in treatment, the empirical coverage of all fevers in the ICU with antibiotics is not necessary [ 3].
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