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In recent years, we have begun to understand the benefits of a well composed intestinal flora, emphasizing a role for health promoting pro- and prebiotics.
Estradiol antagonized PI3K inhibitor-induced apoptosis following short-term estrogen deprivation, emphasizing a role for estrogen-deprivation therapy in promoting PI3K inhibitor activity in the first-line setting.
One important mediator of the DNA-damage response, chk1, negatively regulates G2/M transition via its centrosomal localization, emphasizing a role for centrosomes in the DNA-damage response.
We have identified UBF as the first common interaction partner of CTCF and CTCFL, emphasizing a role for these proteins in the organization of rDNA chromatin.
This lack of gender bias also distinguishes 15q duplication autism from idiopathic cases, emphasizing a role for the genes within the duplication in the etiology of the autism phenotype.
In conclusion, our results provide new insights into the genes and pathways that might regulate the dysfunction and death of neurons expressing mutant polyQs, emphasizing a role for specific metabolic, developmental and pro-survival pathways.
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Consistent with this characterization, investigations into the biological function of bNOS have also emphasized a role for NOS-dependent nitrate and nitrite production in aerobic and microaerobic respiration.
Altogether, our results emphasize a role for Fyn activation to restrain the inhibitory potential of Erk1/2 on PPARγ Ser-84, therefore allowing a maximal response of PPARγ to ghrelin.
We report that the Δppk2 mutant displayed deficiency in several survival- and virulence-related phenotypes, which emphasizes a role for PPK2 in mediating stress tolerance and pathogenesis in C. jejuni.
This result further emphasizes a role for the hippocampus beyond the spatial domain.
Taken together, this emphasizes a role for lamin B, in the very early stages of progeroid disease development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com