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We must emphasize limitations (ascertainment bias; selection bias; small numbers; predominance of paediatric cases in published data), but one could hypothesize that missense mutations are more frequent in patients with longer survival, testable with a prospective longitudinal study.
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Although the number of reports on QTL mapping of agronomically important traits in plants has increased tremendously in the past 20 years, several authors have also emphasized limitations and biases of QTL mapping that have limited their broad application to marker-assisted breeding in many crops.
We point to three main lessons from this analysis: 1) Attention to high standards in geocoding is valuable, as less rigorous approaches led to different results; 2) Individual level confounding is a threat to valid associations; and 3) Side of highway and predominant wind direction affected associations, emphasizing limitations in proximity measures.
Power calculations based on previous studies of this SNP [odds ratio of GG versus CC genotypes >2.0; (14)] emphasized limitations of the genetic association study design (0.11 for PSC-CCA versus PSC without CCA, 0.14 for PSC-CCA versus healthy controls; http://medipe.psu.ac.th/episoft/pssamplesize) to conclusively clarify whether this mutation may play a role in cholangiocarcinogenesis in PSC.
She can do this in several ways: by impeaching them, by emphasizing limitations on their ability to perceive, or by eliciting testimony that they have been convicted of a crime of moral turpitude.
You can do this in several ways: by impeaching them, by emphasizing limitations on their ability to perceive, or by eliciting testimony that they have been convicted of a crime of moral turpitude.
Studying the simplicity of Rogers's pink powder room — how it was designed to whimsically emphasize its limitations rather than trying to mask them — I began to reconsider the seemingly intractable constraints of my small office.
NCAR scientists emphasize the limitations of the model.
Finally, we emphasize the limitations and advantages of the model and of the experimental results presented.
Malvy was careful to emphasize the limitations of what he called a "noncomparative, proof-of-concept" study.
Randomization tests effectively emphasize the limitations of SSDs, especially those with a large factor to run size ratio.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com