The results added on to the genetic heterogeneity of CADASIL and emphasized difficulties in designing algorithms for molecular diagnosis.
In correspondence with Malebranche, Gottfried Wilhelm Leibniz (1646 1716) emphasized difficulties with Descartes's conservation law, and that correspondence led Malebranche to insert into a 1700 edition of the Lois the admission that experience reveals that such a law does not hold.
Previous studies have emphasized difficulties in obtaining adequate follow-up rates.
Psychological and psychosocial issues are often reported as particularly important barriers to diabetes care by patients, emphasizing difficulties that some have with the strictness of the diabetes regimen, including diet, exercise and monitoring [ 6].
When Roiphe posits a split between her mother's generation of feminists women eager to enter the world and seize sexual freedom and those of today, who emphasize the difficulties of doing either, she has it wrong, and not just historically.
Other authors focus on challenges in the clinical application of WGS and emphasize the difficulties in integrating the patient into the information system [19, 22].
"More generally, the FOIA example nicely emphasize the difficulties (for the lack of a better word) of the use of the word anonymous and, IMHO, the issue its preponderance in our legal framework raises," he adds.
These data indicate that ATRA does not promote the expansion of cells with a durable Treg phenotype, and furthermore, these data emphasize the difficulties of using FOXP3 expression as the sole surrogate for Treg activity.
Moreover, parents may emphasize practical difficulties when explaining missed appointments to GPs to avoid blame and maintain positive relationships.
