The emergence of techniques such as in vivo imaging of brain function in humans and genetic engineering in rodents has provided important new insights into the impact of serotonin (5-HT), a key modulator of emotional behavior, on neural systems subserving anxiety and depression.
The LCSPT circuits initially were related to emotional behavior on the basis of their anatomical connectivity with visceral control structures that mediate emotional expression, such as the hypothalamus and periaqueductal gray (PAG) (Nauta and Domesick 1984).
These abnormal brain regions are predominantly located in the limbic-cortical-striatal-pallidal-thalamic tract (LCSPT) [ 20, 21], which is considered related to emotional behavior on the basis of its anatomical connectivity with visceral control structures that mediate emotional expression [ 19].
Several functional relationships exist between drinking parents and the emotional behaviors of their offspring.
Evidence from neuroimaging, neuropathological, and lesion analysis studies implicates brain networks that normally regulate the evaluative, expressive and experiential aspects of emotional behavior in the pathophysiology of mood disorders (Phillips et al. 2003).
To get further insight of how LSAMP is involved in the regulation of adaptive and emotional behavior by the usage of alternative promoters, we studied behavioral correlates for Lsamp 1a and 1b transcripts in three brain areas.
We have argued that changes in BNST PACAP signaling may mediate the changes in emotional behavior and dysregulation of the HPA axis associated with anxiety and mood disorders.
We studied the control of emotional behavior, rather than focusing on perceptual aspects of emotion processing as previously done (Hermans et al. 2008; Derntl et al. 2009; Manuck et al. 2010; Root et al. 2009; Stanton et al. 2009; Van Wingen et al. 2009).
Deficits in the domains of affective links and emotional behavior are other aspects of ASD [2] [4].
Here, we show that testosterone influences the cerebral correlates involved in the control of social emotional behavior by modulating anterior portions of the VLPFC bordering the FP, rather than those portions of the orbitofrontal cortex previously associated with emotional processing (Derntl et al. 2009; Manuck et al. 2010; Mehta and Beer 2010; Van Wingen et al. 2010).
