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Neuropsychological Rehabilitation arose from the traditional rehabilitation models, in which the rehabilitation of the motor and linguistic problems is given precedence to; an approach centered on the intervention on cognitive, behavioral and emotional alterations that are a consequence of brain damage.
Apart from these cognitive and emotional alterations, to our knowledge no study has investigated the occurrence of early psychiatric symptoms in R6/1 mice.
Altogether, these data suggest the presence of selected emotional alterations in pre-motor R6/1 mice, which appear less robust than the cognitive deficits.
Moreover, the presence of functional polymorphisms and subsequent deficits in expression/processing in rodents and patients leads to signs of both central diabetes insipidus and emotional alterations, e.g. decreased anxiety-related behavior [13] [16].
The presence of sleep disturbances and other somatic symptoms [ 2], together with emotional alterations [ 3], define a clinical condition with an important impact upon patient life [ 4].
Furthermore, literature suggests that age is associated with depression, as well as other emotional alterations ; therefore, age could also influence patients with obesity to develop depression.
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Such a closely matched control could serve to increase confidence that CBM-I tasks achieve change in emotional vulnerability via alteration of specific patterns of selective interpretation and not any more general exposure to emotionally valenced stimuli.
Stress, particularly when uncontrollable, excessive and/or prolonged, can produce a myriad of emotional and cognitive alterations [2] [4].
31% of the patients in groups I and G II demonstrated impaired emotional functioning or alterations in affect.
Various neural deficits, including mental retardation, have been identified in a small proportion of patients, although most patients are not formally examined for cognitive, emotional or behavioral alterations.
Although Atf3 has long been recognised as a stress-response gene, recent cumulative evidence has suggested that ATF3 is involved in more general adaptive responses, such as environmental, emotional and nutritional alterations [ 11– 13].
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