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In this hypothesis, SGI1 may predict the next emerging Salmonella serotype.
Recent events include the rapid dominance of an emerging Salmonella Typhi haplotype, termed H58, associated with multidrug resistance and occasional reduced fluoroquinolone susceptibility [ 4– 7].
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It has recently emerged that Salmonella encodes two actin-binding proteins, SipC and SipA, which together efficiently nucleate actin polymerization and stabilize the resulting supramolecular filament architecture.
Also, plasmid-mediated resistance to macrolides may emerge in Salmonella spp., which is also a target of azithromycin.
A recent report from neighboring Cameroon suggests that quinolone resistance has emerged among Salmonella enterica serovar Typhi there [ 50] and we have reported quinolone resistance in epidemic Vibrio cholerae from Ghana [ 51].
"When we were in the thick of it, the name that came up again and again was DeCoster Egg Farms," said Paul A. Blake, who was head of the enteric diseases division of the Centers for Disease Control and Prevention in the 1980s, when investigators began to tackle the emerging problem of salmonella and eggs.
Additionally, NGS technology revealed considerable genomic stability and high reproducibility for SNP targets used in the clustering of closely related isolates within an important and emerging serovar of Salmonella enterica.
Such knowledge could prove key to making sense of the emerging epidemiology of invasive Salmonella disease and help predict Salmonella epidemics.
Here we describe an emerging approach to monitor Salmonella typhimurium infection progression using in vivo fluorescence upon parenteral infection.
Unpasteurized juice has been implicated in outbreaks of Salmonella and emerging pathogens such as E. coli O157 H7 (Table 4.1).
"By better understanding how Salmonella evolves to cause systemic disease in humans, we can better assess how dangerous emerging strains or outbreaks of Salmonella might be and mount the appropriate public health response," Monack says.
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