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Such an evolutionary bottleneck (Merlo et al, 2006) may provide a therapeutic window of opportunity to target the emerging resistant clone, whereas genetic heterogeneity and hence the potential for drug resistance to evolve is low.
Moreover, this underscores the urgent need for new antibiotics active against the emerging resistant pathogens.
These can act against a broad spectrum of enteroviruses, but emerging resistant virus variants threaten their efficacy.
Since emerging resistant pathogens will challenge healthcare facilities in future even more than today, well-designed studies addressing the role of disinfection in the healthcare-setting are needed.
Typing of bacterial isolates has been used for decades to study local outbreaks as well as in national and international surveillances for monitoring newly emerging resistant clones.
Recommendations for appropriate antimicrobial therapy should be based on PK/PD parameters, with the aim of achieving the maximum potential for eradication of both existing and emerging resistant pathogens.
Similar(33)
When antibiotics eliminate sensitive strains more quickly, the opportunity for sensitive strains to become resistant is decreased; however, once resistance has emerged, resistant strains have a stronger selective advantage.
This paper identifies the features of TB control programs that alter the likelihood of novel MDR-TB strain emergence and the extent of spread of newly emerged resistant strains.
Pugnacious auteurs emerged, resistant to TV formulas.
During the past 60 70 years, N. gonorrhoeae has repeatedly demonstrated its enormous ability to develop resistance in a rapid manner to all antimicrobial drugs introduced for first-line therapy, along with a large capacity for the prompt spread of the emerged resistant strains globally [ 3, 4, 6- 12].
The emerging multidrug resistant (MDR) and extensively drug resistant (XDR) Mycobacterium tuberculosis (MTB) infection is increasing with greater complexity, estimated 220000-400000 tubercasesis casemergedged in 2011 globally.
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