Withdrawal symptoms from antidepressants are measured using the Discontinuation Emergent Signs and Symptoms (DESS) scale [ 25].
A Discontinuation Emergent Signs and Symptoms (DESS) scale was used at the 32 week or discontinuation visit and at a follow up visit 2 weeks later to assess withdrawal symptoms [ 12].
The frequency and severity of spontaneously reported adverse events were recorded weekly along with prompted reports of adverse events of interest (treatment emergent signs and symptoms) covering somnolence, increased excitability, mood swings, rash, hypothermia, and cough.
Because symptoms of relapse and withdrawal can occur acutely and resolve in a short period of time, the pain, Clinical Opiate Withdrawal Scale (COWS), and Discontinuation Emergent Signs and Symptoms (DESS) scale are repeated three times a week during AI episodes to determine if withdrawal symptoms occurred.
On day 35, withdrawal symptoms were assessed with the Discontinuation-Emergent Signs and Symptoms (DESS) Scale [ 27].
The primary outcome of that study was MADRS total score, and the secondary outcome was a measure of Discontinuation-Emergent Signs and Symptoms (DESS), a scale used to evaluate SSRI-discontinuation symptoms.
Finally, the prevalence and severity of an antidepressant discontinuation syndrome will be measured in those who withdraw from medication using the Discontinuation-Emergent Signs and Symptoms (DESS) Scale [ 35].
An important addition to this study was the inclusion of the Discontinuation-Emergent Signs and Symptoms (DESS) checklist, which was used to evaluate adverse events that occurred or worsened during and after the seven-day taper period when the medication was discontinued.
Abdun-Nabi told me his company was still trying to develop that vaccine, but critics question whether Emergent, which signed another contract this month to deliver $1.25 billion more of the old vaccine to the stockpile, is pursuing the replacement vaccine as enthusiastically as possible.
Treatment-emergent vital sign abnormalities are summarized in Table 3.
