With the emergence of enzyme replacement therapies, early diagnosis of this multisystem disease is crucial.
This requires continued surveillance to monitor for the emergence of serotype replacement.
This growth would be mainly accelerated by the pharmaceutical and diagnostics industry, the largest end-users of these enzymes which will continue to grow due to the emergence of enzyme replacement therapies and innovations in thrombolytics.
In their study on aging and hair cycles over an exceptionally long duration of 8 to 14 years, Courtois et al (1995) found a reduction in the duration of hair growth and in the diameter of hair shafts, and a prolongation of the interval separating the loss of a hair in telogen and the emergence of a replacement hair in anagen (latency phase).
No, the American public is not about to start taking its meals in communal dining rooms, but a sign of the times is the emergence of "home-meal replacement" chains like Boston Chicken, Inc., which now has 1,100 Boston Market outlets and $1.2 billion in gross revenues.
The need for general physicians and non-geneticist medical specialists to know more about Hunter disease has become increasingly pressing as a result of the emergence of lysosomal enzyme replacement therapy (ERT), which significantly improves the outcome for patients, but only if the treatment is initiated early, before the development of serious irreversible complications[ 19- 21].
However, the long term effectiveness of PCV-7 also depends on the emergence of serotype and species replacement disease as the vacant niche is replenished by non-vaccine pneumococcal serotypes or possibly other respiratory pathogens that share the nasopharyngeal niche [ 20, 21].
That evidence implies the possibility that the emergence and replacement of FJ-like virus was preceded by and facilitated by the vaccination program, although the mechanism remains unknown epidemiologically and virologically (some researchers consider that the emergence and replacement of FJ-like virus are questionable [24], [25]).
We considered a mechanism for the emergence and replacement of the FJ-like virus over a large geographical region in China using a more complex patch-structured model in the heterogeneous area [31].
This result shows the possibility that the emergence and replacement of the resistant strain can be facilitated by the vaccination program, as in some vaccination programs [19], [21], [22].
Our data showed that the CPV epizootic in Brazil followed the same pattern observed in the USA of emergence of CPV-2 followed by replacement by the variants CPV-2a and 2b.
