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Results of these evolutionary simulations show that under such a selective pressure, mutational processes easily lead to the emergence of pathways with two separate sub-pathways (i.e. modules) each mediating a distinct response only to one of the signals.
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Thus, the emergence of metabolic pathways allowed primitive organisms to become increasingly less dependent on exogenous sources of organic compounds.
It facilitates the appearance of drug resistance in microorganisms, as well as the emergence of bioremediation pathways for anthropogenic toxins.
The key characteristic of the kinetics model in Scheme 1 is the emergence of branched pathways from the initial encounter complex, having Michaelis states of differing reactivity.
The emergence of biochemical pathways that produce and then utilize ketone bodies is believed to be a major selective force in the evolutionary history of Homo sapiens and this adaptive process, along with others, enables human adults to survive for more than two months without food intake [ 1].
The study builds on the path creation literature, which seeks to explain the emergence of new technological pathways.
Furthermore, the emergence of endogenous immunoregulatory pathways and active pro-resolving mediators hold great potential for future therapeutic intervention.
The adaptation of organisms to a parasitic life style is often accompanied by the emergence of novel biochemical pathways absent in free-living organisms.
In this framework, the emergence of new synthetic pathways could proceed in two steps, as follows.
Our work sheds light on the fundamental problem of metabolic diversification and the emergence of shared catabolic pathways.
More largely this will pertain to an understanding of the emergence of signal transduction pathways during the acquisition of multicellularity in the Metazoa.
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