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It has proven possible to select functional nucleic acids from even relatively small random sequence pools, giving greater credence to the de novo emergence of function at even the earliest junctures.
This precise topography therefore underlies the emergence of function of motor nuclei and motor circuits in the nervous system.
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As an alternative, a phylogenetic approach can complement the functional studies to get new insights on the emergence of functions and classification of this family of enzymes.
This example shows how the emergence of enzymatic function can be explored based on signatures of the prototypes and their elementary chemical functions.
As different functions are encoded by different genes and simultaneous emergence of both functions is unlikely, first one function must have evolved and then the other.
We treat the emergence of monetary function as a problem in mechanism design, modeled by minimal strategic market games that overcome a generalized Jevons failure when agents must commit ahead of time to specialist resource production.
The availability of non-mammalian vertebrate animal models has the potential to provide insight into the emergence of diverse function in the aquaporins.
The evolution of CGB illustrates the process of gene duplication followed by neofunctionalization. Notably, the emergence of new function involved changes in both the coding sequence and nearby noncoding sequence, which provided a new regulatory context.
Focus may also be expanded to different time points in the life cycle, to not only the developmental emergence of cognitive function but also the stabilization, maintenance and eventual decline, having potential translational value in the treatment of neurodegenerative disease.
The rate of neofunctionalization in the absence of gene duplication (the emergence of new function in orthologs) is also related to the accessibility of this pleiotropic walk, but is expected to be even slower than that of neofunctionalization in the absence of subfunctionalization.
The study of gene duplications continues to be at the forefront of molecular evolution due to their likely role in the emergence of new functions (Bridges 1936; Ohno 1970; Conant and Wolfe 2008; Ponting 2008; Hahn 2009; Innan and Kondrashov 2010).
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