Activated E-cadherin transcriptional repressors play specific physiological roles during development, but they can re-emerge and become activated in disease.
They found that Wnt4 was initially limited to the collecting ducts, with an induction of HG, and subsequently, Wnt4 was activated and emerged in the interstitial area [ 22].
Activation of STAT5, as determined by tyrosine phosphorylation, decreases during metastatic progression of breast cancer, and in a large patient cohort, activated STAT5 emerged as an independent prognostic marker for good prognosis in women with breast cancer [ 43].
As panic ensued after the rig caught fire, witnesses have testified, questions emerged about who should activate vital emergency equipment and call to abandon ship.
Recent clinical data have emerged demonstrating that activating mutations in the KRAS gene predict resistance to treatment with inhibitors of the epidermal growth factor receptor (EGFR).
XMLV is carried by most strains of mice in the form of endogenous viral genomes integrated in the chromosomes of the mouse germ line and inherited as Mendelian traits, but that can be activated to emerge as potentially infectious virus particles.
In chronic liver diseases emerging evidences suggest that activated hepatic stellate cells were not the only key players in the hepatic fibrogenic process and that other cell types, either hepatic (i.e. hepatocyte, biliary epithelial cell and portal fibroblast) or extra-hepatic (bone marrow-derived cells and circulating fibrocytes) could contribute to this process through EMT [ 6– 8].
Once biomarkers are available, approaches to prevention and treatment should take advantage of the emerging evidence that activating brain plasticity together with targeted behavioral interventions is a promising strategy.
Three active roles emerged from the analysis: (a) objects activating interpretations, (b) objects stimulating collaborative practices, and (c) objects sparking experimental activities.
A sensitivity toward the earth, and an emerging planetary awareness is being activated as a result.
