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The C. elegans coiled-coil protein AJM-1 localizes to apical junctions and is required for embryonic elongation and maintenance of epithelial integrity [41], [42].
In C. elegans proteins of DMPK family are expressed in hypodermal cells and are involved in embryonic elongation [ 49].
Interestingly, mec-8; fbn-1 tm290 fbn-1 tm290rested uniformutantsembryos arresteded to complete embryonic elongation.
(D ) Reversal of embryonic elongation in mec-8 ; sqt-3 (e2117ts ) mutants leads to a decrease in keyhole depth.
The production of axial tissues during embryonic elongation is driven by posteriorly-located progenitors emerging round the end of gastrulation.
Although embryonic elongation was arrested, the head appeared to develop normally, allowing us to visualize developmental apoptosis events (Fig. 1Eb).
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The vertebrate homologues of Drosophila 'core' PCP genes regulate many developmental processes, including convergent extension (CE) cell movements in embryonic axis elongation, orientation of mechanosensory hair cells in the cochlea, and the arrangement of fur, feathers and scales (Seifert and Mlodzik, 2007).
We conclude that while eps-8 is essential for morphogenetic cell shape changes of embryonic epidermal elongation, it may act later in this process than does VAB-19.
Then the germinated seed enters the second process (a plateau phase) and the third process (the embryonic axes elongation).
Mutation in components of the PCP pathway, including Dact1, Sestd1, and Dvl2, lead to a CE deficit during embryonic axis elongation and to neural tube defects.,, Biochemical interactions between the Dvl2 and Sestd1 proteins suggest that mutations at the corresponding loci may genetically interact in functionally revealing ways.
These neuromesodermal progenitors (NMPs) are the source of new axial structures during embryonic rostrocaudal axis elongation and are marked by the simultaneous co-expression of the transcription factors T(Brachyury) (T(Bra)) and Sox2.
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