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Failure to identify an embryonic demise, or diagnosing embryonic demise in a live IUP.
Reduction of Tie1 levels in mouse embryos with a hypomorphic Tie1 allele resulted in abnormal lymphatic patterning and architecture, decreased lymphatic draining efficiency, and ultimately, embryonic demise.
One hypothesis is that embryonic demise is due to leaky vessels or cardiac pathology.
When we crossed Pkd1cond/cond and Pkd1+/−, Tie2-Cre+ mice we found a reduction in live born Pkd1cond/−; Tie2-Cre+ animals (referred to as Pkd1endo−), indicating that endothelial cell loss of polycystin-1 results in the embryonic demise of a significant fraction of animals (Table 1).
(4) Laboratory experiments using pregnant rats have demonstrated that repeated EA at forbidden points throughout gestation does not influence rates of post-implantation embryonic demise or cause miscarriage, fetal loss or resorption.
However, tissue slicing and staining cannot provide a real-time model for further investigation and, as FGF-9 is critical to embryonic development, a conventional transgenic approach could cause early defects, or even embryonic demise, interfering with in-depth study.
Similar(52)
Thus, Matr3 plays an essential role in early mouse embryonic survival, with significant demise in Matr3Gt-ex13 homozygous embryos occurring before E4.5 and the demise of all remaining embryos occurring between the E4.5 implantation and E8.5 neural fold stages.
Embryonic, practically.
Its demise deterred imitators.
Its demise was certain.
The demise came quickly.
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