Sentence examples for embryonic branching from inspiring English sources
In this study, we report assembly of kidney organoids that recapitulate embryonic branching morphogenesis.
It is therefore unclear whether the observed delay in embryonic branching reflects the generalized runting that results from EGFR or ADAM17 ablation, strain-specific genetic effects, the lack of local EGFR signaling, or a combination thereof.
For instance, mice lacking the estrogen-regulated homeobox transcription factor MSX2 form mammary buds that fail to undergo embryonic branching, thus concealing any role that MSX2 might have in adolescent branching [ 5].
For instance, adolescent branching requires estrogen and estrogen receptor-α (ER-α), adult tertiary side-branching requires progesterone and its receptor (PR), and embryonic branching is hormone independent, because it occurs in mice lacking ER-α, ER-β, PR or the receptors for growth hormone (GH) and prolactin [ 8, 9].
At both E15.5 and E18.5, embryonic lung branching did not appear to be affected by lack of mesenchymal Sox9 expression.
Interestingly, upon analysis of the isolectin B4 (IB4) staining, a marker that highlights the extracellular matrix surrounding fetal blood vessels, eDC placentas exhibited a significant decrease in the number of embryonic vascular branches when compared with control mice.
Sox9 is also a key regulator of embryonic kidney epithelial branching [ 16].
The broad systemic or lethal effects of ablating a particular molecule may also obscure its local role in embryonic and adolescent branching, although the latter can often be addressed through transplantation.
Bioinformatic analysis of ovarian tumors in hens led to the identification of a group of highly up-regulated genes that are involved in the embryonic process of branching morphogenesis.
While tags found in sub-branch A11 typically demonstrate a peak in expression during embryonic day, sub-branch A12 mainly contains tags with expression levels peaking around postnatal day, as shown in Figure 6(g).
Mutations in mouse Vangl genes encoding core PCP proteins cause neural tube defects (NTDs) and Vangl2 mutations also impair branching of embryonic mouse lung airways.
