Researchers at Eli-Lilly and GlaxoSmithKline are embarking on trials of drugs aimed at blocking the actions of nerve cells that receive their instructions from "neurotransmitter" molecules called adenosine and glutamate.
The old ones still work most of the time and regulatory changes have made designing and testing new ones much more expensive.The companies need the carrot of a profitable market before they will embark on an expensive series of clinical trials; yet another antibiotic is not guaranteed to provide them with one.
Thus, promising therapies identified through previous research in rodents can be screened for efficacy in this 'clinical model' before embarking on human trials.
Therefore, before embarking on large expensive clinical trials targeting or manipulating specific variables, it is of paramount importance to conduct thorough studies adequately addressing the role and interactions of various risk factors.
Researchers at Cedars-Sinai Medical Center in Los Angeles are preparing to embark on human trials after promising results in rabbits.
We suggest that there is sufficient supportive evidence to embark on clinical trials of inorganic arsenic in the treatment of advanced human breast cancer.
These factors should be taken into consideration by clinicians discussing elevated PSA results with patients and those planning to embark on future trials investigating dietary modification interventions for the prevention of a PC diagnosis.
The researcher who wishes to embark on a trial using minimisation as the means of patient allocation often has many questions to ask.
11 Given the growing problem of obesity and lack of clarity on effective approaches to prevention, it would be unwise to embark on another trial without thorough attention to the early phases described in the MRC framework.
The company was about to embark on Phase III trials — the large, expensive, double-blind, placebo-controlled trials that are required for F.D.A. approval — when the results of a long-term-toxicity test came in.
