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Only one study has so far detected mutations in other emb (embA and embC) or other genes conferring resistance to EMB in epidemiologically unrelated EMB-resistant strains [ 13].
Mutations in the embB gene and those within its conserved EMB resistance determining region (ERDR) in particular have repeatedly been associated with resistance to EMB in Mycobacterium tuberculosis.
These features require specific implementation approach to utilize the capacity of each EMB in highest possible degree.
The aim of this study was to identify the mutation that confers resistance to ethambutol (EMB) in Mycobacterium tuberculosis in comparison with the phenotypic drug susceptibility test (DST).
EMB is generally not indicated in this specific clinical scenario, according to the scientific statement regarding the role of EMB in the management of cardiovascular disease published by the American Heart Association AHAA), the American College of Cardiology (ACC), and the European Society of Cardiology (ESC) [48].
We did not find any resistance to EMB in this study.
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Some evidence also supported that T270I changed on its own and plays no role in EMB resistance in embC [ 28] and that T270I is not a marker for EMB resistance in the M. tuberculosis complex [ 29].
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In addition, performing EMBs in the elderly is technically not more difficult than in younger patients.
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