Their identification will therefore require a combination of approaches that include site-specific mutagenesis, elucidation of its crystal structure and a careful comparison with the known structure of the H. neapolitanus carboxysomal enzyme (PDB ID: 1SVD; Kerfeld, CA et al, 2005).
Prospective studies with the CD8-depleted, SIV/macaque model that include functional examination of the cardiovascular system will facilitate elucidation of the mechanism of myocardial toxicities that result from combined NRTI therapy.
The popularity of the challenge attracted the attention of a new group of chemists, specifically Ph.D. students, seeking out answers to structure elucidation problems that could be included into their thesis.
We note that this definition includes some important technical terms and concepts that, in turn, need defining and further elucidation.
Issues that require further research include elucidation of site-specific differences in fat cells, the use of vacuum-assisted lipoplasty and ultrasound-assisted lipoplasty in procuring stem cells, and the development of more efficient and convenient tissue processing techniques.
This includes elucidation of the early responses to systemic iron perturbations or alterations in erythropoietic activity that translate into hepcidin regulation.
The isolation and characterization of Arabidopsis thaliana mutants that are defective in NPQ has proven to be a useful approach for the elucidation of factors that are involved in NPQ, including various electron transport components that affect ΔpH generation.
The typical method for the elucidation of PA-neutralizing monoclonal antibodies includes a wide screen and the selection of antibodies that bind to adsorbed PA (direct ELISA format), and only then the best binders were screened for their ability to neutralize PA in the LeTx assay.
Over the past decade, tremendous progress has been made in the elucidation of mechanisms that promote postnatal lung development, including extensive data suggesting that impaired pulmonary angiogenesis contributes to the pathogenesis of BPD.
Note that Brouwer did not include this elucidation in the published paper (1926A), nor in later presentations.
A structure elucidation encompasses several tasks including data collection, library searching and fragment assembly.
