C. concisus genomospecies are frequently detected in human disease (5, 15 ; this study); elucidation of their pathogenicity should be considered a public health research issue.
Ideally, studies aiming at further elucidation of these mechanisms should be performed in original human glioma tissue and in (orthotopic) models that genotypically and phenotypically closely mimic the situation in human glioma patients [ 147, 154].
Their marginal expression may regulate important cellular and biochemical functions, but this requires further elucidation, and and their expression should be more finely tuned.
A major goal of future proteomic studies should be the elucidation of proteome dynamics during oocyst transition from the unsporulated to the metabolically active, sporulating state, until the development of infectious, metabolically quiescent, sporozoites.
Because ALK could be a potent molecular target of NB therapy, elucidation of the NeuroD1-ALK axis should be beneficial for clinical purposes.
This information should be helpful for the elucidation of the environmental sensing strategy of C. cellulovorans.
More research efforts should be directed towards the elucidation of risk factors of yersiniosis in this age group.
This strategy should be applicable for the elucidation of regulatory pathways in other systems by using the extensive sequencing data currently being generated.
For this reason, in vivo testing should be considered for further elucidation of the clinical relevance of the combination of ET-743 and radiotherapy.
More importantly, elucidation of this unique sugar-assimilation mechanism should be of great importance in developing superior microorganisms for industrial biotechnology.
