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Not much is known about the topological and structural determinants of 11β-HSD 1, although the elucidation of the structure of 11β-HSD 1 would be a great advantage in identifying specific 11β-HSD 1 inhibitors.
Everyone in biophysics realised that elucidation of the structure of DNA would lead to new, crucial insights into the biochemistry of replication and the underlying coding and function of genetic material in living things, an aspect of biology hitherto shrouded in mystery.
The result was the most important finding in the history of biology apart from the discovery of evolution by natural selection: the elucidation of the structure of DNA.They were an odd couple.
Synge used paper chromatography to work out the exact structure of the simple protein molecule gramicidin S, which helped to pave the way for the English biochemist Frederick Sanger's elucidation of the structure of the insulin molecule.
Nevertheless, Pauling was awarded the 1954 Nobel Prize for Chemistry "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances".
Elucidation of the structure of cell lectins with currently five main families aids to tailor ligand characteristics rationally.
Similar(20)
Describing, understanding, and modulating the function of the cell require elucidation of the structures of macromolecular assemblies.
The elucidation of the structures of alkaloids a-c was approached using a user database adjusted for cryptolepine structure analysis.
In recent years, the elucidation of the structures of many signalling molecules has allowed new insights into the molecular mechanisms that govern signal transduction events.
We have confirmed the high efficiency and applications of the StrucEluc system and the methodology of its application by the elucidation of the structures of more than 300 complex natural compounds.
These advances arose from the identification of ∼80 proteins in SSVs, elucidation of the structures of pertinent macromolecular complexes, utilisation of different serotypes (A G) of botulinum neurotoxin (BoNT) together with transgenic mice lacking key genes.
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