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Further elucidation of the precise mechanism of IL-1β processing in mechanical ventilation-induced inflammation could provide novel targets for the future treatment of VILI [40].
Because of its small size, the GnRH (gonadotropin-releasing hormone) receptor (GnRHR) is an excellent model for GPCR (G protein-coupled receptor) and has allowed elucidation of the precise biochemical mechanism of pharmacoperone action necessary for rational design of new therapeutic agents.
Elucidation of the precise mechanism(s) awaits further studies.
Elucidation of the precise mechanisms for unregulated B-cell proliferation as a result of AID deficiency is an important unresolved issue.
While elucidation of the precise actions of PINK1 has to await the identification of PINK1-phosphorylation substrates, in Pink1−/− brain the bioenergetic deficit is clearly more prominent than mitochondrial dynamics failure.
Thus, it was surmised that, for elucidation of the precise roles of IL-33 in vivo and in vitro, it would be more advantageous to use neutralizing Abs for IL-33 rather than for ST2.
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The elucidation of these precise mechanisms will help to develop more efficient anti-aging strategies as well as facilitate a better understanding of age-related risks for cancer genesis.
Elucidation of the exact mechanism(s) involved requires further investigation.
Its development as a drug preceded the elucidation of its precise inhibitory mechanism, as well as its molecular targets.
The elucidation of their precise function for TLT function will need further work.
The precise elucidation of the molecular targets of miR-181 may provide important insights this issue.
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