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Thus, elucidation of the functional architecture of the HuAChE active center is bound to be of considerable utility in the current effort to design novel covalent AChE inhibitors as therapeutics for Alzheimer's disease (AD).
However, the elucidation of the functional significance of these results requires further study.
Also, the discovery of Prod1 orthologs in model organisms such as the mouse or zebrafish would likely accelerate the elucidation of the functional mechanism of Prod1 action.
Study of the adaptive maintenance of molecular variation historically has followed one of two approaches, elucidation of the functional components of molecular adaptations at the biochemical level, or description of the historical footprints of selection acting on sequence variants [3].
They call for further elucidation of the functional predestination of large stores of immunoreactive but enzymatically silent GS in epidermis particularly in stratum corneum as well as of regulatory mechanisms controlling its enzymatic activity, and especially of the role of circulating ammonia in establishment of the epidermal permeability barrier.
Elucidation of the functional role of Saha-UD in the devil remains to be determined.
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Further investigation into the regulation of the GJA1-43k/-20k ratio in vitro and in vivo, together with the elucidation of the exact functional consequences of this fragment, is warranted.
BIGA is a powerful tool to analyze large amounts of gene expression data, and will facilitate the elucidation of the underlying functional mechanisms in living organisms.
Elucidation of many of the functional roles of PKA in regulating various cellular processes relies on bioluminescence-based cellular assays.
These studies aided the discovery of biomass-degrading enzymes and the elucidation of the evolutionary and functional relevance in these systems.
In this context, the elucidation of the molecular and functional features of MtbPRPPase is mandatory.
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