Other substitution patterns are also possible, including N-acetylation and 3-O-sulfation of the glucosamine, as well as non-sulfated iduronate and β-D-glucuronate, and 2-O-sulfation of glucuronate, providing considerable sequence heterogeneity [9] and making the structural elucidation of heparin challenging.
Furthermore, this breakdown of homology modeling utility with low target-template identity challenges elucidation of structures for newly discovered proteins, several of which happen to fall into the twilight and midnight zones [26], [29], [30].
A number of epidemiological studies have demonstrated that osteoarthritis has a major genetic component, although elucidation of this has proven challenging [ 2].
These challenges notwithstanding, elucidation of epigenetic control of bone regulation may have translational implications; for example, some demethylating agents are already used to treat neoplastic disorders.
Reproduction of their article pays tribute to their accomplishment, highlights how important sarcoma biology has been to the elucidation of fundamental cancer mechanisms, and challenges orthopaedic investigators to aspire to the highest level of scientific accomplishment.
While much further progress is still needed in the area of lipid analytics, one of the biggest challenges is elucidation of biological phenomena behind the large amounts of lipidomics data currently available.
Specification of primordial germ cells (PGCs) activates epigenetic reprogramming for totipotency, the elucidation of which remains a fundamental challenge.
The clinical presentation of rheumatoid arthritis (RA) poses intriguing challenges to the elucidation of underlying pathogenesis.
The development of sensitive, easy and reliable methods for the determination of Rhizomucor pusillus rennin (MPR) activity, in free and in immobilized form, along with the elucidation of the mechanism of action, represent challenges for the widespread use of the enzyme in industrial cheese production.
This challenge motivates the elucidation of the mechanisms involved in calcification, with the eventual goal of alternative preventative and therapeutic strategies.
Moreover, the common binder matrices are far from pure, making elucidation of the underlying emission mechanisms somewhat challenging, though nonetheless functional.
