For example, elucidation of phenomena associated with adhesion of chondrocytes to biomaterials is critical in addressing the difficult problem of articular cartilage regeneration.
Pedology, as a unique subdiscipline of soil science, contributes inordinately to Earth science, including, for example, elucidation of field variability, surficial weathering processes, Earth system dynamics, and vadose zone flow and transport.
The paradigm of Aβ amyloid structure elucidation provides an example of an innovative experimental design and endeavor, echoing the computational testing of possible molecular associations, all reflected in the current Ma-Nussinov-Tycko model of the Aβ amyloid.
Fig. 3 An example structural elucidation defined in our CSCCP problem.
These include, for example, the elucidation of protein protein relations in terms of ligand or cavity topological similarity via quantitative measures and the prediction of unreported potential ligand-target interactions by detecting potentially cross-binding ligands.
For example, better elucidation of the molecular events responsible for establishing and maintaining pathogenicity might improve optimal drug and vaccine design [ 9].
In the following, PPV is used as an example for elucidation of some of the physiological mechanisms and to expose the contents of the black box.
For example, more elucidation is required on the exact stoichiometry of TatA proteins per substrate and complex before such information can be incorporated into iJL1678-ME.
In addition to its well-established role in structural elucidation, we present recent examples that illustrate the combined power of selective isotope labeling, relaxation dispersion experiments, chemical shift analyses, and computational approaches for the characterization of conformational sub-states in proteins and enzymes.
Notable examples include elucidation of the effects of lead on IQ and the links between arsenic and cancer.
The first example was the elucidation of the alizarin structure in 1868 (see above History of dyes: Natural dyes), followed a year later by its synthesis.
