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Chimeric receptors should prove useful for elucidating the structural basis of receptor function.
A crystal structure of Cul2 in complex with EloBC and a substrate receptor (e.g. VHL) would help in elucidating the structural basis of selectivity for Cul5 rather than Cul2, but has yet remained elusive (see Note added in proof).
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The solution NMR structure and the crystal structures elucidated the structural basis for its high efficiency and directed our efforts of engineering that led to rational design of a functional minimized RadA intein.
Multiple crystal structures elucidate the structural basis of multi-ligand gating in GsuK, and also reveal a unique ion conduction pore with segmented inner helices.
In order to elucidate the structural basis of inhibition, we determined the structure of GPb complexed with the phosphoramidate at 1.83 Å resolution.
In order to elucidate the structural basis of their inhibition, the crystal structures of these compounds in complex with GPb at 1.95 2.23 Å resolution were determined.
To elucidate the structural basis for RNA binding, the solution structure of the Vts1 SAM domain, in the presence of a specific target RNA, has been solved by multidimensional heteronuclear NMR spectroscopy.
Three-dimensional structures of both xylanases were superimposed to elucidate the structural basis for differences in their hydrolytic properties.
To elucidate the structural basis of its reduced potency, we determined the ligand structure in complex with GPb at 1.8 Å resolution.
To elucidate the structural basis for this interaction, we have solved the crystal structure at 2.9 Å resolution of Nef (residues 54 203) in complex with the α (residues 1 396) and σ2 (full-length) subunits of AP-2.
To elucidate the structural basis for this issue, we are currently trying to solve crystal structures of both forms with RNA substrates.
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