Molecular markers, such as nucleotide sequence patterns, have proven useful for elucidating modes and chains of transmission or identifying new risk groups and factors.
Looking forward, multidisciplinary research papers elucidating modes of action or critical steps in biologic pathways that result in toxicity would be consistent with this tradition.
The participants concluded that, although there are hurdles to pass on the road to regulatory acceptance, omics technologies are already useful for elucidating modes of action of toxicants and can contribute to the risk assessment process as part of a weight-of-evidence approach.
We conclude that techniques that have been used to measure permeability and transport in other epithelia may help elucidate modes of action of environmental agents on airways.
Elucidating the mode of action and thereby opening the way to the design of chemotherapeutic agents is one of the major goals of metal-based anticancer research.
Further research efforts in this project will be directed to testing the efficacy of the ligand-protected curcumin nanoparticles against other microbial species, elucidating the mode of antimicrobial action of the particles and their interaction with bacterial cell, and using the particles for preparing active antimicrobial food-contact surfaces.
The main object of this study is elucidating the mode of natural selection on macaque CYP1A2.
Elucidating the mode of action behind these observed antibacterial properties, as well as exploring other pharmacological activities is currently underway in our lab.
We further intend to analyse the motifs present in the piRNA clusters and classify them into plausible families as well as elucidating their mode of target binding.
Further discussions stressed the necessity of elucidating the mode of evolution of multidomain proteins, particularly in the context of domain rearrangements.
However, the identification of the active component in smoke (i.e. KAR1) presents enhanced opportunities for elucidating the mode of action of this compound in the absence of artefacts and confounding influences caused by the additional compounds in smoke.
