In comparing the results from the anatomically complex model with a more simplified representation of the same dataset, we provide a first glimpse into differences made by fine structural detail on the electrical activation dynamics as well as elucidate instances where global activation patterns are similar.
These technologies have been used to define the underlying biology of CLL (for instance, elucidating the cell of origin of this lymphoid malignancy [ 6]), as well as to explore clinical questions (such as how to predict clinical outcome in a highly variable disease on the basis of molecular indicators [ 7]).
For instance, further elucidating the connection between team skill and the observed scoring patterns would provide an important connection between within-game dynamics and team-specific characteristics.
Our group could, for instance, elucidate an involvement of disturbed Wnt signalling, which is crucial for epithelial proliferation but also Paneth cell antimicrobial function, in chronic small intestinal inflammation (Koslowski et al, 2012; Wehkamp et al, 2007).
Accordingly, within a single spectrum whole-cell mass spectrometry would capture generic activation patterns as well as activation event specific from distinct signalling pathways which remain to be elucidated using for instance, top-down proteomic approaches [ 39].
In this instance, Jowitt does well by elucidating the facts without commentary.
It may also be used as a preliminary input module for modeling approaches elucidating phenomena further downstream, as they are, for instance, related to DARPP-32 signaling [14], [20].
Future studies aimed at elucidating concordant physiological, and ultimately (macro molecular, underpinnings of disparate instances of longevity would benefit from heeding analyses that reduce or eliminate the likelihood of suspected mechanisms.
Tractable models of many human cancers now exist in which the initiating genetic lesions have been elucidated and, in some instances, where the cooperating lesions are also known.
However, nearly all previous simulations of NaV channels started from prokaryotic structures, therefore incapable of elucidating the unique eukaryotic properties arising from the asymmetric amino acid distribution, for instance, the role of DEKA in cation selection.
Research examining cognitive-affective processing - for instance, through functional brain imaging and neurocognitive approaches - may be useful in elucidating the complex pathways from risk factor (genetic or environmental) to disorder.
